| Pathway Id | ko03018 |
| Class & Sub-Class | Class: Genetic Information Processing Sub-Class: Folding sorting and degradation |
| Description | The correct processing; quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes; two major pathways of mRNA decay exist and both pathways are initiated by poly(A) shortening of the mRNA. In the 5' to 3' pathway; this is followed by decapping which then permits the 5' to 3' exonucleolytic degradation of transcripts. In the 3' to 5' pathway; the exosome; a large multisubunit complex; plays a key role. The exosome exists in archaeal cells; too. In bacteria; endoribonuclease E; a key enzyme involved in RNA decay and processing; organizes a protein complex called degradosome. RNase E or R interacts with the phosphate-dependent exoribonuclease polynucleotide phosphorylase; DEAD-box helicases; and additional factors in the RNA-degrading complex. Source: KEGG Database |
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